Hopital Europeen Georges-Pompidou, Vascular and Oncological Interventional Radiology, Paris (France) Inserm (Institut national de la sante et de la recherche medicale) U970, Paris (France) Universite Paris Descartes, Paris (France) Thiounn, Nicolas [Assistance Publique Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Urology, Paris (France) Hopital Europeen Georges-Pompidou, Vascular and Oncological Interventional Radiology, Paris (France) Hopital Necker, Radiology Department, Paris (France) Pellerin, Olivier Sapoval, Marc [Assistance Publique Hopitaux de Paris. Hopital Europeen Georges-Pompidou, Vascular and Oncological Interventional Radiology, Paris (France) Correas, Jean-Michel [Assistance Publique Hopitaux de Paris. Hopital Europeen Georges-Pompidou, Vascular and Oncological Interventional Radiology, Paris (France) Department of Radiology, Taichung Veterans General Hospital, Taichung City (China) Amouyal, Gregory Pereira, Helena Del Giudice, Costantino Dean, Carole [Assistance Publique Hopitaux de Paris. Lin, Yen-Ting [Assistance Publique Hopitaux de Paris. Identified patterns could be particularly insightful and lead to a better understanding of the molecular mechanisms underlying FASD.Ĭan prostatic arterial embolisation ( PAE) reduce the volume of the peripheral zone? MRI evaluation of zonal anatomy and infarction after PAEĮnergy Technology Data Exchange (ETDEWEB) It should also allow recognition of patterns linking gestational timing, dosage, and duration of PAE, such as recognizing that binge alcohol exposure(s) during early gestation can lead to severe FASD outcomes. Analysis of these data should provide a valuable tool for researchers wishing to choose the PAE model best suited to their research questions or to investigate established PAE models for FASD comorbidities. In this review we examine mouse models of PAE and focus on those with demonstrated craniofacial malformations, abnormal brain development, or behavioral phenotypes that may be considered FASD-like outcomes. In animal models, variables such as nutrition, genetic background, health, other drugs, and stress, as well as dosage, duration, and gestational timing of exposure to alcohol can all be controlled in a way that is not possible in a clinical situation. The potential impact of prenatal alcohol exposure ( PAE) varies considerably among exposed individuals, with some displaying serious alcohol-related effects and many others showing few or no overt signs of fetal alcohol spectrum disorder (FASD). Petrelli, Berardino Weinberg, Joanne Hicks, Geoffrey G Effects of prenatal alcohol exposure ( PAE): insights into FASD using mouse models of PAE.
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